Tianeptine oxalate salts and polymorphs
AssigneeTonix Pharma Holdings Limited
InventorsStefano Luca Giaffreda, Enrico Modena, Serena Fabbroni, Michel Chiarucci, Mark T. Edgar
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Abstract
Disclosed herein is an oxalate salt/co-crystal (tianeptine oxalate) of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (tianeptine) as shown in Formula I:
Claims21
A pharmaceutical composition comprising an anhydrous crystalline hemi-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (anhydrous crystalline tianeptine hemi-oxalate salt) and a pharmaceutically acceptable carrier or excipient, wherein the anhydrous crystalline tianeptine hemi-oxalate salt is characterized by an X-ray diffraction pattern (XRPD) comprising at least one peak selected from the group consisting of 8.2, 8.6, 9.1, and 9.5 degrees 2θ±0.3 degrees 2θ.
A pharmaceutical composition comprising an anhydrous crystalline mono-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (anhydrous crystalline tianeptine mono-oxalate salt) and a pharmaceutically acceptable carrier or excipient, wherein the anhydrous crystalline tianeptine mono-oxalate salt is characterized by an X-ray diffraction pattern (XRPD) comprising at least one peak selected from the group consisting of 10.1 and 10.5 degrees 2θ±0.3 degrees 2θ.
A pharmaceutical composition comprising a mixture of an anhydrous crystalline hemi-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide and an anhydrous crystalline mono-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide, and a pharmaceutically acceptable carrier or excipient, wherein the mixture is characterized by an XRPD pattern comprising at least one peak selected from the group consisting of 10.1, 10.5, 15.8, and 19.2 degrees 2θ±0.3 degrees 2θ.
A pharmaceutical composition comprising two or more layers, each layer comprising one or more of:
- (a) an anhydrous crystalline hemi-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (anhydrous crystalline tianeptine hemi-oxalate salt), wherein the anhydrous crystalline tianeptine hemi-oxalate salt is characterized by an X-ray diffraction pattern (XRPD) comprising at least one peak selected from the group consisting of 8.2, 8.6, 9.1, and 9.5 degrees 2θ±0.3 degrees 2θ;
- (b) an anhydrous crystalline mono-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (anhydrous crystalline tianeptine mono-oxalate salt), wherein the anhydrous crystalline tianeptine mono-oxalate salt is characterized by an X-ray diffraction pattern (XRPD) comprising at least one peak selected from the group consisting of 10.1 and 10.5 degrees 2θ±0.3 degrees 2θ;
- or
- (c) a mixture of (a) and (b);
- wherein one layer is substantially released prior to the substantial release of another layer in vivo.
A method of producing an anhydrous crystalline hemi-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide, said method comprising the following steps:
- (a) preparing a mixture of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide free base and oxalic acid in acetone;
- (b) heating the mixture of step (a) to about 40° C. 60° C. to afford a solution;
- (c) cooling the solution of step (b) to about 25° C. to form a precipitate comprising the anhydrous crystalline hemi-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide;
- and
- (d) recovering the precipitate of step (c) to afford the anhydrous crystalline hemi-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide.
A method of producing a mixture of an anhydrous crystalline hemi-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide and an anhydrous crystalline mono-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide, said method comprising the following steps:
- (a) dissolving (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide free base in acetone to afford solution A;
- (b) heating solution A to reflux;
- (c) adding oxalic acid to the refluxing solution A of step (b) to afford solution B;
- (d) cooling solution B to about 40° C. 60° C. to form a precipitate comprising the mixture of the anhydrous crystalline hemi-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide and the anhydrous crystalline mono-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide;
- and
- (e) recovering the precipitate of step (d) to afford the mixture of the anhydrous crystalline hemi-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide and the anhydrous crystalline mono-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide.
A method of producing an anhydrous crystalline mono-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide, said method comprising the following steps:
- (a) dissolving (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide free base in ethyl acetate to afford a mixture;
- (b) heating the mixture of step (a) to about 40° C. −60° C. to afford a solution;
- (c) cooling the solution of step (b) to about 25° C. to afford solution A;
- (d) dissolving oxalic acid in ethyl acetate to afford solution B;
- (e) adding solution B to solution A at about 25° C. to form a precipitate comprising the anhydrous crystalline mono-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide;
- and
- (f) recovering the precipitate of step (e) to afford the anhydrous crystalline mono-oxalate salt of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide.
Dependencies are inferred from the claim text.