Method for treating cancer
AssigneeEpizyme, Inc.
InventorHeike Keilhack
Life of this patent
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Abstract
The present invention provides a method for treating or alleviating a symptom of a disorder, e.g., immune evasion, cancer-cell induced immune dysfunction, reduced immune response, lowered inflammation, decreased expression of a major histocompatibility complex (MHC), or cancer, characterized by aberrant, misregulated, or increased Enhancer of Zeste Homolog 2 (EZH2) activity in a cell or subject in need thereof by contacting the cell or administering to the subject a therapeutically effective amount of an EZH2 inhibitor.
Claims11
A method for screening the effectiveness of a treatment of immune evasion, cancer-cell induced immune dysfunction, reduced immune response, or decreased expression of a major histocompatibility complex (MHC) in a human subject in need thereof comprising:
- (1) obtaining a first and a second biological sample from the subject;
- (2) contacting the second biological sample with an EZH2 inhibitor;
- (3) assaying the first and the second biological sample for expression of a MHC;
- and
- (4) comparing expression of the MHC in the first biological sample to expression of the MHC in the second biological sample;
- wherein the treatment comprises an EZH2 inhibitor;
- and
- wherein if the second biological sample has increased expression of the MHC when compared to expression in the first biological sample, then the treatment comprising the EZH2 inhibitor is more likely to be effective in the subject.
Dependencies are inferred from the claim text.