Therapeutically active compounds and their methods of use

A method for preparing a compound of Formula (Ia) wherein:

• ring A is selected from phenyl, pyrazolyl, oxazolyl, isoxazolyl, pyridinyl, pyrimidinyl, pyrazinyl, and thiazolyl, wherein ring A is optionally substituted with up to two substituents independently selected from halo, —C1-C4 alkyl, —C1-C4 haloalkyl, —C1-C4 hydroxyalkyl, —NH-S(O)2-(C1-C4 alkyl), —S(O)2NH(C1-C4 alkyl), —CN, —S(O)2-(C1-C4 alkyl), C1-C4 alkoxy, —NH(C1-C4 alkyl), —OH, —OCF3, —CN, —C(O)NH2, —C(O)NH(C1-C4 alkyl), —C(O)-N(C1-C4 alkyl)2, and cyclopropyl optionally substituted with OH;
• R1, R3, R4, and R6 are each independently selected from hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, —O-C1-C4 alkyl, and CN, wherein each said alkyl moiety of R1, R3, R4, and R6 are each independently optionally substituted with —OH, —NH2, —CN, —O-C1-C4 alkyl, —NH(C1-C4 alkyl), or —N(C1-C4 alkyl)2;
• R2 and R5 are each independently selected from:
• —(C1-C6 alkyl), —(C1-C6 alkyl)-C(O)-NH2, —(C2-C6 alkenyl or alkynyl), —(C1-C6 alkylene)-O-(C1-C6 alkyl), —(C0-C6 alkylene)-C(O)N(R6)-(C1-C6 alkyl), —(C0-C6 alkylene)-Q and —(C0-C6 alkylene)-C(O)-(C1-C6 alkyl), wherein:
• any alkyl or alkylene moiety present in R2 and R5 is optionally substituted with one or more —OH, —O(C1-C4 alkyl), —CO2H, or halo;
• any terminal methyl moiety present in R2 and R5 is optionally replaced with —CH2OH, CF3, —CH2F, —CH2CL, C(O)CH3,C(O)CF3, CN, or CO2H;
• Q is selected from carbocyclyl and heterocyclyl, and of which is substituted with 0-3 instances of halo, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, =O, —C(O)-C1-C4 alkyl, and CN;
• wherein
• R1 and R2 are optionally taken together to form a carbocyclyl or a heterocyclyl either of which is optionally substituted with up to 3 substituents independently selected from halo, e.g., fluoro, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, —CN, =O, —OH, aryl, heteroaryl, —SO2C1-C4 alkyl, —CO2C1-C4 alkyl, —C(O)aryl, and —C(O)C1-C4 alkyl;
• or
• R4 and R5 are optionally taken together to form a carbocyclyl or a heterocyclyl either of which is optionally substituted with up to 3 substituents independently selected from halo, e.g., fluoro, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, —CN, =O, —OH, aryl, heteroaryl, —SO2C1-C4 alkyl, —CO2C1-C4 alkyl, —C(O)aryl, and —C(O)C1-C4 alkyl;
• R7 and R8 are H;
• comprising a reaction between