Methods of treating or alleviating joint diseases by administering an inhibitor of discoidin domain receptor 1 (DDR1)
AssigneeKaohsiung Medical University
InventorsChau-Zen Wang, Chung-Hwan Chen, Liang-Yin Chou, Yu Chou, Mei-Ling Ho, Yi-Hsiung Lin
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Abstract
The present invention relates to a use of Discoidin Domain Receptor 1 (DDR1) inhibitor in preparing a medicament for preventing or treating a joint disease. The present invention further relates to a use of DDR1 activator in preparing a medicament for preventing or treating abnormalities of endochondral ossification-related conditions.
Claims16
A method for treating or alleviating a joint symptom associated with degenerative arthritis in a subject, comprising:
- identifying the subject having the degenerative arthritis;
- and
- administering to the subject an effective amount of a composition including a Discoidin Domain Receptor 1 (DDR1) inhibitor,
- wherein the DDR1 inhibitor is
A method for treating or alleviating a degenerative joint disease in a subject, comprising:
- administering to the subject an effective amount of a composition including a Discoidin Domain Receptor 1 (DDR1) inhibitor for treating or alleviating the degenerative joint disease in the subject,
- wherein the DDR1 inhibitor is
A method for reducing, inhibiting, mitigating or alleviating at least one of a cartilage degradation and a chondrocyte death in a subject suffering therefrom, comprising:
- administering to the subject an effective amount of a Discoidin Domain Receptor 1 (DDR1) inhibitor, thereby reducing, inhibiting, mitigating or alleviating the at least one of the cartilage degradation and the chondrocyte death in the subject,
- wherein the DDR1 inhibitor is
Dependencies are inferred from the claim text.