Loading patent…
AssigneeArvinas Operations, Inc.
InventorsAndrew P. Crew, Jing Wang, Hanqing Dong, Yimin Qian
Estimating the term…
The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) TBK1. In particular, the present invention is directed to compounds, which contain on one end an E3 ubiquitin ligase binding moiety which binds to an E3 ubiquitin ligase and on the other end a moiety which binds TBK1 such that TBK1 is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of TBK1. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of TBK1.
A bifunctional compound comprising the chemical structure:
A TBK1 binding moiety having the chemical structure:
A method of making a bifunctional molecule comprising the chemical structure TBM-L-ULM, the method comprising:
A bifunctional compound comprising the chemical structure:
Dependencies are inferred from the claim text.