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US 10,946,016 B2Granted
Solid forms of an epidermal growth factor receptor kinase inhibitor
AssigneeCelgene CAR LLC
InventorMei Lai
Life of this patent
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Abstract
The present invention provides a solid form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibit desirable characteristics for the same.
Claims17
A process for preparing a crystalline solid form of Compound 1:
- comprising combining Compound 1 with a suitable solvent to provide a mixture;
- and isolating the crystalline solid form of Compound 1 from the mixture, wherein:
- the crystalline solid form of Compound 1 is unsolvated and is Form A, characterized by having one or more peaks in its X-ray powder diffraction pattern selected from those at about 6.73, about 18.30, about 18.96 and about 25.48 degrees 2-theta;
- or
- the crystalline solid form of Compound 1 is unsolvated and is Form B, characterized by having one or more peaks in its X-ray powder diffraction pattern selected from those at about 10.67, about 12.21, about 18.11, about 19.24 and about 21.53 degrees 2-theta;
- or
- the crystalline solid form of Compound 1 is a dimethylformamide solvate and is Form C, characterized by having one or more peaks in its X-ray powder diffraction pattern selected from those at about 16.32, about 18.82, about 20.26, about 22.58 and about 25.36 degrees 2-theta;
- or
- the crystalline solid form of Compound 1 is a 1,4-dioxane solvate and is Form D, characterized by having one or more peaks in its X-ray powder diffraction pattern selected from those at about 18.40, about 19.31, about 20.14, about 20.53 and about 25.25 degrees 2-theta;
- or
- the crystalline solid form of Compound 1 is a methyl ethyl ketone solvate and is Form E, characterized by having one or more peaks in its X-ray powder diffraction pattern selected from those at about 5.78, about 12.57, about 15.34, about 19.10 and about 24.80 degrees 2-theta;
- or
- the crystalline solid form of Compound 1 is a N-methyl-2-pyrrolidone solvate and is Form F, characterized by having one or more peaks in its X-ray powder diffraction pattern selected from those at about 15.51, about 16.86, about 18.80, about 20.97 and about 23.32 degrees 2-theta;
- or
- the crystalline solid form of Compound 1 is a N-methyl-2-pyrrolidone solvate and is Form G, characterized by having one or more peaks in its X-ray powder diffraction pattern selected from those at about 6.79, about 17.86, about 19.43, about 19.98 and about 22.35 degrees 2-theta;
- or
- the crystalline solid form of Compound 1 is a hydrate and is Form H, characterized by having one or more peaks in its X-ray powder diffraction pattern selected from those at about 10.82, about 11.08, about 18.45, about 22.85 and about 25.06 degrees 2-theta;
- or
- the crystalline solid form of Compound 1 is a hydrate and is Form I, characterized by having one or more peaks in its X-ray powder diffraction pattern selected from those at about 6.13, about 12.22, about 15.91, about 18.35, about 18.88, and about 21.90 degrees 2-theta.
16 more elements
Dependencies are inferred from the claim text.