Methods for inducing tumor regression, inhibiting tumor growth, and inducing apoptosis in breast tumors with geranylgeranyltransferase I inhibitors
AssigneesH. Lee Moffitt Cancer Center and Research Institute, Inc., Yale University
InventorsSaid M. Sebti, Andrew D. Hamilton
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Abstract
Methods of inducing tumor regression, inhibiting tumor growth, and inducing apoptosis with selective peptidomimetic inhibitors of geranylgeranyltransferase I (GGTase I), are provided. In one aspect, GGTI-2418 and its methylester GGTI-2417, increase levels of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 and induce breast tumor regression in vivo. In another aspect, GGTI-2417 inhibits the Cdk2-mediated phosphorylation of p27Kip1 at Thr187 and accumulates p27Kip1 in the nucleus.
Claims4
A method of treating breast cancer in a subject in need thereof, comprising:
- assaying a breast cancer sample comprising breast cancer cells from the subject for nuclear p27 levels;
- comparing the nuclear p27 levels to a control level of nuclear p27;
- detecting breast cancer cells in the breast cancer sample having nuclear p27 levels that are below control levels of nuclear p27;
- and
- administering a therapeutically effective amount of GGTI-2418 to the subject.
Dependencies are inferred from the claim text.