Treatment of autoimmune diseases with combinations of RXR agonists and thyroid hormones
AssigneeIo Therapeutics, Inc.
InventorsRoshantha A. Chandraratna, Martin E. Sanders
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Abstract
The present specification provides methods of treating autoimmune diseases with a combination of a RXR agonist and a thyroid hormone.
Claims19
A method of treating an autoimmune disease, wherein the autoimmune disease is an arthritis, the method comprising administering, to an individual in need thereof, a therapeutically effective amount of a RXR agonist and a thyroid hormone, wherein the RXR agonist has the structure of Formula II
- wherein R is H or lower alkyl of 1 to 6 carbons;
- or a pharmaceutically acceptable salt thereof;
- wherein administration of the RXR agonist and the thyroid hormone treats the autoimmune disease in the individual more effectively than either the RXR agonist or the thyroid hormone alone.
A method of treating an autoimmune disease, wherein the autoimmune disease is an arthritis, the method comprising of administering, to an individual in need thereof, a therapeutically effective amount of a combination of 3,7-dimethyl-6(S),7(S)-methano,7-[1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphth-7-yl]2(E),4(E) heptadienoic acid (IRX4204), and thyroxine;
- and wherein administration of the combination reduces severity of the autoimmune disease in the individual more effectively than either the IRX4204 or the thyroxine alone.
Dependencies are inferred from the claim text.