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US 10,946,000 B2Granted
Method for treating cancer with combination therapy
AssigneeRedHill Biopharma Ltd.
InventorsReza Fathi, Dror Ben-Asher, Danielle Abramson
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Abstract
Provided are methods for treating cancer in a patient by administering at least one antibiotic selected from the group consisting of clofazimine, rifabutin and clarithromycin, in combination with an aryladamantane compound. In an embodiment, the aryladamantane compound is [3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide], or a pharmaceutically acceptable salt thereof.
Claims19
A method for treating a solid tumor cancer comprising:
- administering to a patient with a solid tumor cancer:
- (i) a first pharmaceutical composition comprising a therapeutically effective amount of a first compound, wherein the first compound is 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridine-4-ylmethyl)-amide or a pharmaceutical acceptable salt thereof;
- and
- (ii) a second pharmaceutical composition comprising a therapeutically effective amount of a second compound, wherein the second compound is N-α-(2,4,6-triisopropylphenylsulfonyl)-3-hydroxyamidino-phenylalanine-4-ethoxycarbonylpiperazide, a stereoisomer, a racemic mixture, a metabolite, a salt, crystal, or any combination thereof.
1 more element
Dependencies are inferred from the claim text.