US 10,945,997 B2Granted

Polymer derivative of macrolide immunosuppressant

AssigneeNippon Kayaku Kabushiki Kaisha

InventorsNao Yoneki, Akihiro Sekiguchi, Kana Mizunuma, Yuki Kobayashi, Junpei Konno, Kan Saiga, Keiichirou Yamamoto

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Abstract

An object of the invention is to obtain a preparation which shows enhanced effectiveness and safety compared to tacrolimus, has the concentration in blood maintained at a constant level without individual differences, whereby the control of the amount of administration depending on the blood kinetics (blood trough concentration) becomes unnecessary. The present invention relates to a polymeric derivative of tacrolimus, in which a polyethylene glycol segment and an alcoholic hydroxy group of tacrolimus are bonded to side-chain carboxy groups of a polyaspartic acid derivative.

Claims25

Dependent claims

A polymeric derivative of tacrolimus, comprising a polyaspartic acid derivative, a polyethylene glycol segment, and tacrolimus,

wherein the polyethylene glycol segment and an alcoholic hydroxy group of tacrolimus are bonded to side-chain carboxy groups of the polyaspartic acid derivative.

Dependencies are inferred from the claim text.

Facts

Application: 16/066,692Filed 19 Dec 2016
Priority: JP JP2016-0026788 Jan 2016
Published: US 2020/0155518 A121 May 2020
Granted: 16 Mar 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 31/436
Ortho- or peri-condensed with heterocyclic ring systems: the heterocyclic ring system containing a six-membered ring having oxygen as a ring…
C08G 69/40
Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule: polyamides containing…
A61K 47/60
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes: the organic…
A61K 47/645
Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is…:…

Family

US 2020/0155518 A1Pre-grant publication · published 21 May 2020
US 10,945,997 B2This patent

From the US filing history. Foreign family members aren’t listed.

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