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US 10,945,989 B2Granted
Perinatal treatment with a flavonoid agonist of the TrkB receptor for BDNF rescues neurogenesis and behavior in the Ts65Dn mouse model of DS
AssigneeAlma Mater Studiorum - Università di Bologna
InventorsRenata Bartesaghi, Fiorenza Stagni
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Abstract
The present invention relates to methods of restoring brain development in individuals with Down syndrome with a flavone derivative, 7,8-dihydroxyflavone (7,8-DHF).
Claims8
A method of decreasing likelihood of developing intellectual disability in subjects affected by Down syndrome said method comprising:
- administering a pharmaceutical composition comprising an effective amount of a TrkB receptor agonist to said subjects and
- decreasing the likelihood of said intellectual disability in said subjects, wherein said TrkB receptor agonist is 7,8-dihydroxyflavone.
A method of treating intellectual disability in subjects affected by Down syndrome said method comprising:
- administering a pharmaceutical composition comprising an effective amount of a TrkB receptor agonist to said subjects and
- treating said intellectual disability in said subjects, wherein said TrkB receptor agonist is 7,8-dihydroxyflavone.
Dependencies are inferred from the claim text.