Fumarate ester dosage forms
AssigneeBanner Life Sciences LLC
InventorsJason M. Vaughn, Justin R. Hughey, Tanesha Roberts, Tatyana Dyakonov, Sunil Agnihotri, Aqeel A. Fatmi
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Abstract
Described herein are pharmaceutical compositions comprising fumarate esters, methods for making the same, and methods for treating subjects in need thereof. In particular, oral controlled release pharmaceutical compositions comprising fumarate esters suspended in liquid matrices are described. One embodiment described herein is a pharmaceutical composition comprising fumarate esters suspended in a lipid or lipophilic liquid with enhanced bioavailability.
Claims13
An oral pharmaceutical composition comprising an immediate releasing single phase non-aqueous liquid vehicle comprising a suspension of a fumarate ester or a salt thereof having the formula:
An oral pharmaceutical composition comprising an immediate releasing single phase non-aqueous liquid vehicle comprising:
- mono- and di-glycerides, polyvinylpyrrolidone, and polyoxyl 40 hydrogenated castor oil, and lactic acid;
- and
- a suspension of about 95 mg of a fumarate ester or a salt thereof having the formula:
Dependencies are inferred from the claim text.