Sphingosine kinase type 1 inhibitors and uses thereof
AssigneesEnzo Therapeutics, Inc., Virginia Commonwealth University
InventorsSarah Spiegel, Robert Elliot Zipkin, Jeffrey Kroll Adams
Life of this patent
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Abstract
Provided are inhibitors of sphingosine kinase Type I that are useful in a number of applications, indications and diseases, as well as for monitoring pharmacokinetics and patient management. These compounds are applicable to treating ischemic diseases such as myocardial infarction and stroke.
Claims20
A method for treating myocardial infarction in a patient, comprising:
- administering to a patient in need of treatment for myocardial infarction a compound having the formula
A method for treating myocardial infarction in a patient, comprising:
- administering to a patient in need of treatment for myocardial infarction a compound having the formula
- wherein R comprises a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, a branched carbon chain comprising one or more heteroatoms, a cyclic ring, a heterocyclic ring, an aromatic ring, a hetero-aromatic ring, or any combination of the foregoing.
A method for treating myocardial infarction in a patient, consisting essentially of:
- administering
- to the patient.
A method for treating stroke in a patient, comprising:
- administering to a patient in need of treatment for stroke a compound having the formula
A method for treating stroke in a patient, comprising:
- administering to a patient in need of treatment for stroke a compound having the formula
- wherein R comprises a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, a branched carbon chain comprising one or more heteroatoms, a cyclic ring, a heterocyclic ring, an aromatic ring, a hetero-aromatic ring, or any combination of the foregoing.
A method for treating stroke in a patient, consisting essentially of:
- administering
- to the patient.
Dependencies are inferred from the claim text.