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US 10,945,966 B2Granted
PEGylated lipid nanoparticle with bioactive lipophilic compound
AssigneeEyesiu Medicines B.V.
InventorsPieter Jaap Gaillard, Jacob Rip
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Abstract
The invention relates to nanoparticles for the systemic or topical delivery of lipophilic diagnostic or therapeutic agents to a subject in need thereof. The nanoparticles of the invention comprise a water soluble polymer and at least one of a biocompatible lipid and a lipophilic agent. The invention further relates to ophthalmic treatment using the nanoparticles of the invention. In addition, the invention pertains to compositions and formulations comprising the nanoparticle of the invention. Such formulation may be an eye drop formulation.
Claims8
A nanoparticle comprising:
- a) two or more phospholipids;
- and,
- b) at least one acylethanolamide,
- wherein the nanoparticle has a surface comprising a water soluble polymer wherein the water soluble polymer is conjugated to one of the two or more phospholipids.
1 more element
Dependencies are inferred from the claim text.