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US 10,945,962 B2Granted
Controlled-release peptide compositions and uses thereof
AssigneeBoard of Regents of the University of Nebraska
InventorsJoseph A. Vetro, Sam D. Sanderson
Life of this patent
Estimating the term…
Abstract
Controlled-release formulations of carboxy-terminal C5a analogs (such as sustained-release formulations of the analogs), and their use in methods for treating and preventing an infection or a disease such as cancer, for directly killing microorganisms, for vaccine preparation, for inducing an immune response and for targeting antigen-presenting cells and other cells bearing a C5a receptor, are provided.
Claims17
A controlled-release formulation comprising:
- an encapsulating material having an external surface,
- a therapeutic or prophylactic compound encapsulated in said encapsulating material, and
- a C5a analog attached to the external surface of the encapsulating material, said C5a analog being a C5a receptor agonist having response-selective C5a receptor binding activity, said binding activity comprising activation of antigen presenting cells,
- wherein the C5a analog is selected from the group consisting of:
- (SEQ ID NO:
- 4)
- (a)
- Tyr-Ser-Phe-Lys-Asp-Met-Pro-MeL-(D-Ala)-Arg;
- (SEQ ID NO:
- 3)
- (b)
- Tyr-Ser-Phe-Lys-Pro-Met-Pro-Leu-(D-Ala)-Arg;
- (SEQ ID NO:
- 7)
- (c)
- Tyr-Ser-Phe-Lys-Asp-Ala-Pro-Leu-(D-Ala)-Arg;
- (SEQ ID NO:
- 8)
- (d)
- Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-(D-Ala)-Arg;
- (SEQ ID NO:
- 9)
- (e)
- Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-Gly-Arg;
- (SEQ ID NO:
- 10)
- (f)
- Tyr-Ser-Phe-Lys-Asp-Ala-Pro-Leu-Gly-Arg;
- (SEQ ID NO:
- 11)
- (g)
- Tyr-Ser-Phe-Lys-Asp-Cys-Pro-Leu-Gly-Arg;
- (SEQ ID NO:
- 12)
- (h)
- Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-(D-Pro)-Arg;
- (SEQ ID NO:
- 13)
- (i)
- Tyr-Ser-Phe-Lys-Asp-Met-Gln-Leu-(D-Ala)-Arg;
- (SEQ ID NO:
- 14)
- (j)
- Tyr-Ser-Phe-Lys-Asp-Met-Gln-Leu-Gly-Arg;
- (SEQ ID NO:
- 15)
- (k)
- Tyr-Ser-Phe-Lys-Asp-Met-Gln-Pro-Gly-Arg;
- (SEQ ID NO:
- 16)
- (l)
- Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-Aib-Arg;
- (SEQ ID NO:
- 17)
- (m)
- Tyr-Ser-Phe-Lys-Gly-Met-Pro-Leu-Gly-Arg;
- and
- (SEQ ID NO:
- 18)
- (n)
- Tyr-Ser-Phe-Lys-Gly-Leu-Leu-Leu-Gly-Arg.
58 more elements
Dependencies are inferred from the claim text.