Implants for bone and cartilage repair
AssigneeCollagen Matrix, Inc.
InventorsShu-Tung Li, Hui-Chen Chen, Debbie Yuen
Life of this patent
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Abstract
An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.
Claims15
A biocompatible and bioresorbable implant having a physically and mechanically stable bi-phasic structure for the repair of bone and cartilage, comprising a cell conductive zone that contains a first matrix of first type I collagen fibers, the first type I collagen fibers having a length of 1 cm to 50 cm, and an osteoconductive zone consisting of a second matrix of second type I collagen fibers also having a length of 1 cm to 50 cm and calcium-containing mineral particles, wherein the first matrix of first type I collagen fibers is a demineralized bone matrix, the calcium-containing mineral particles include carbonate apatite and have a size of 0.2 mm to 1.5 mm, the cell conductive zone is free of calcium-containing mineral particles, the first type I collagen fibers extend into the osteoconductive zone and overlap with the second type I collagen fibers, and the cell conductive zone overlaps with and is in direct contact with the osteoconductive zone.
A biocompatible and bioresorbable implant for the repair of bone and cartilage, comprising a matrix consisting of type I collagen fibers having a length of 1 cm to 50 cm, the implant having a cell conductive zone and an osteoconductive zone, wherein the matrix of type I collagen fibers is a demineralized bone matrix, the osteoconductive zone includes calcium-containing mineral particles, the calcium-containing mineral particles include carbonate apatite and have a size of 0.2 mm to 1.5 mm, the cell conductive zone is free of calcium-containing mineral particles, the type I collagen fibers extend from the cell conductive zone into the osteoconductive zone, and the cell conductive zone is in direct contact with the osteoconductive zone.
Dependencies are inferred from the claim text.