Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods

A method for replacement of a native mitral valve having an annulus and leaflets coupled to the annulus, the method comprising:

• positioning a prosthetic device including an anchoring member and a valve support coupled to the anchoring member between the leaflets of the native mitral valve, wherein:
• a first portion of the anchoring member engages tissue on or downstream of an annulus of the native mitral valve such that the first portion of the anchoring member deforms to at least partially conform to a shape of the native mitral valve;
• the valve support is coupled to a second portion of the anchoring member and expands within the anchoring member;
• the first portion is upstream of the second portion;
• the anchoring member extends in an upstream direction and flares radially outwardly apart from a downstream portion of the valve support;
• in an expanded configuration, the first portion of the anchoring member is longitudinally aligned with an upstream end of the valve support;
• and
• a portion of the valve support maintains a predetermined cross-sectional shape upon expansion suitable for operating a prosthetic valve while the first portion of the anchoring member deforms to at least partially conform to the shape of the native mitral valve;
• and
• allowing the anchoring member to expand to an expanded configuration having a dimension larger than a corresponding dimension of the annulus such that upstream movement of the anchoring member is blocked by engagement of the first portion of the anchoring member with the tissue on or downstream of the annulus on an inward-facing side of the leaflets.

A method for replacement of a native heart valve having an annulus and leaflets coupled to the annulus, the method comprising:

• positioning a prosthetic heart valve device including an anchoring member and a valve support coupled to the anchoring member at a native heart valve, wherein:
• an upstream portion of the anchoring member has a first cross-sectional dimension and a downstream portion of the anchoring member has a second cross-sectional dimension less than the first cross-sectional dimension in an expanded configuration;
• the upstream portion engages tissue at the native annulus in the expanded configuration to restrain the anchoring member from movement in an upstream direction;
• the valve support is coupled to the downstream portion of the anchoring member and configured to support a prosthetic valve;
• the valve support has an upstream region and a downstream region;
• and
• with the anchoring member in the expanded configuration, an upstream end of the valve support is radially spaced apart from and longitudinally aligned with the upstream portion of the anchoring member such that the upstream portion of the anchoring member can deform inwardly without substantially deforming the upstream region of the valve support;
• and
• deploying the prosthetic heart valve device into the expanded configuration.