Cell membrane-mimicking brush polymer and method for preparding same

A method for preparing a brush polymer compound, comprising the steps of:

• step (1) of preparing a polyether polymer compound comprising a structure represented by the Formula 6 from the cyclic monomers of the Formula 5 through cationic ring-opening polymerization,
• step (2) of preparing a polymer compound having an azide group and comprising a structure represented by the Formula 7 from the polyether polymer comprising the structure of the Formula 6 in the step (1) through a halogen substitution reaction in an organic solvent and
• step (3) of preparing a brush polymer compound of the Formula 1 using the azide group of the polymer compound having an azide group of the step (2) and the cycloaddition reaction of the alkyne group of the functional molecule:
• in the Formulas 5 and 6, R1 and R2 are hydrogen or an alkyl group having 1 to 20 carbon atoms, ρ is an integer of 0 to 20, d is 50 to 50,000, A is hydrogen, an alkyl group having 1 to 20 carbon atoms or —CH2X (wherein X is F, Cl, Br or I),
• in the Formula 7, R1 and R2 are hydrogen or an alkyl group having 1 to 20 carbon atoms, ρ is an integer of 0 to 20, d is 50 to 50,000 and A′ is H, —CH2N3 or an alkyl group having 1 to 20 carbon atoms,
• wherein,
• R1, R2, R4, R5 and R6 are independently hydrogen or an alkyl group having 1 to 20 carbon atoms;
• R3 is an alkylene having 1 to 20 carbon atoms;
• ρ is an integer of 0 to 20;
• m and n represent the content (mol %) of the polyether unit, 0≤m≤100, 0≤n≤100 and m+n=100;
• Y is H, —CH2X (wherein X is F, Cl, Br or I), an alkyl group having 1 to 20 carbon atoms, UR3N61[R4R5R6] or —ZW;
• Z and U are linkers connecting the terminal functional group and the polyether backbone;
• W is a carbocyclic group of the Formula 2 comprising E1 to E21 and G1 to G32;
• -* represents the point to be connected to Z;
• E1 to E21 are independently selected from the group consisting of C, N, O, P and S;
• provided that E4, E5, E7, E8, E10, E13, E14 and E15 are not O and S;
• when any one of E1 to E21 is O or S, G attached thereto is not present;
• when any one of E1 to E21 is N or P, there is no or at most one G attached thereto;
• G1 to G32, when present, are independently selected from the group consisting of —CHO, COOH, —H, —N3, —NO2, —NH2, —OH, —PO3H, —SH, —SO3H, —CH3, —C6H5 and alkyl group having 1 to 20 carbon atoms, or together form ═O, ═N or ═S with two G's connected to the same E;
• and
• the functional molecule comprises UR3N⊕[R4R5R6] or —ZW at either end, and comprises an alkyne group at the opposite end.