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US 10,872,751 B2Granted
Detectors and methods of using them
AssigneePerkinElmer Health Sciences, Inc.
InventorsHamid Badiei, Steven A. Beres
Life of this patent
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Abstract
Certain embodiments described herein are directed to detectors and systems using them. In some examples, the detector can include a plurality of dynodes, in which one or more of the dynodes are coupled to an electrometer. In some instances, an analog signal from a non-saturated dynode is measured and cross-calibrated with a pulse count signal to extend the dynamic range of the detector.
Claims15
A method of determining the amount of a species in a sample, the method comprising:
- measuring a non-saturated analog signal representative of the species in the sample, in which the non-saturated analog signal is measured with an electron multiplier comprising a plurality of dynodes in which at least two dynodes of the plurality of dynodes are electrically coupled to a respective electrometer, in which the electron multiplier is configured to terminate signal amplification at a dynode where a saturation current is detected, in which the electron multiplier is configured to split a beam into a first beam and a second beam, in which the electron multiplier is electrically coupled to a processor configured to measure the non-saturated analog signal using the first beam and one of the at least two dynodes electrically coupled to its respective electrometer;
- counting pulses using the second beam and the processor to provide a pulse count signal;
- and
- cross-calibrating the measured, non-saturated analog signal and the provided pulse count signal using the processor to determine the amount of species in the sample.
1 more element
Dependencies are inferred from the claim text.