US 10,871,497 B2 · Predicting reagent chiller instability and flow cell heater failure in sequencing systems

Abstract

The technology disclosed detects chiller system instability that reduces false alerts. A smoothed time series of chiller temperature sensor data is tested in a predefined time window for periods of stable operation below a predetermined threshold. The technology disclosed predicts that the reagent chiller is unstable if periods of stable temperature operation are less than a predetermined stability measure or if the stable reagent chiller temperature has exceeded a threshold. The technology disclosed detects flow cell heater failure over multiple cycles in a system. A time series of flow cell heater temperature sensor data is tested to determine if a count of points in a recent process cycle were recorded above a threshold. The technology disclosed determines that a flow cell heater is failing if count of points above a threshold in two consecutive cycles is less than a predetermined count.

Claims25

Dependent claims

A method of detecting chiller system instability comprising:

applying a smoothing function to a time series of chiller temperature sensor data and reducing transient oscillations to produce a smoothed time series of chiller temperature sensor data;
determining that the smoothed time series of chiller temperature sensor data in a predefined time window fails a stable temperature operation criteria in time intervals during which temperature readings in the smoothed time series change by more than a predetermined temperature change rate from interval to interval;
and
generating a notification of unstableness when the smoothed time series of chiller temperature sensor data fails the stable temperature operation criteria in more than a predetermined percentage of the time intervals over the predefined time window.

1 more element

A system including one or more processors coupled to memory, the memory loaded with computer instructions to detect chiller system instability, the computer instructions, when executed on the one or more processors, implement actions comprising:

applying a smoothing function to a time series of chiller temperature sensor data and reducing transient oscillations to produce a smoothed time series of chiller temperature sensor data;
determining that the smoothed time series of chiller temperature sensor data in a predefined time window fails a stable temperature operation criteria in time intervals during which temperature readings in the smoothed time series change by more than a predetermined temperature change rate from interval to interval;
and
generating a notification of unstableness when the smoothed time series of chiller temperature sensor data fails the stable temperature operation criteria in more than a predetermined percentage of the time intervals over the predefined time window.

1 more element

Dependencies are inferred from the claim text.

Predicting reagent chiller instability and flow cell heater failure in sequencing systems

Life of this patent

Predicting reagent chiller instability and flow cell heater failure in sequencing systems

Life of this patent

Abstract

Claims25