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US 10,871,496 B2Granted
Composite compound comprising upconverting nanoparticle and specific receptor
AssigneeGwangju Institute of Science and Technology
InventorsMin-Gon Kim, Hyo-Young Mun, Eun-Jung Jo
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Abstract
Disclosed is a platform detecting glycated hemoglobin as an indicator for diabetes in the blood based on upconverting nanoparticles excited by near-infrared light and luminescence resonance energy transfer.
Claims9
A complex for detecting glycated hemoglobin, comprising:
- (i) a specific receptor for glycated hemoglobin;
- and
- (ii) upconverting nanoparticles bound to the specific receptor,
- wherein the specific receptor for glycated hemoglobin is an antibody that is a material capable of specifically binding to the glycated hemoglobin,
- wherein the upconverting nanoparticles comprise rare earth elements and is free from additional metal nanoparticles,
- wherein the upconverting nanoparticles and the antibody are bound by an amide bond which is formed between a carboxylic group introduced to surfaces of the upconverting nanoparticles and an amine group of the antibody.
3 more elements
Dependencies are inferred from the claim text.