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US 10,871,493 B2Granted
Assay for the diagnosis of peanut allergy
AssigneeEUROIMMUN Medizinische Labordiagnostika AG
InventorsWaltraud Suer, Stefanie Rohwer, Bettina Brix, Alf Weimann
Life of this patent
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Abstract
A diagnostically useful carrier has a polypeptide for specifically capturing an antibody to Ara h 7 isotype 7.0201 in a sample from a subject. A method includes detecting in a sample from a subject the presence or absence of an antibody to Ara h 7 isotype 7.0201. A pharmaceutical composition includes Ara h 7 isotype 7.0201 or a variant thereof.
Claims23
A diagnostically useful carrier, comprising:
- a polypeptide comprising SEQ ID NO:
- 8 for specifically capturing an antibody to Ara h 7 isotype 7.0201 in a sample from a subject, wherein the antibody to Ara h 7 isotype 7.0201 binds to a sequence of SEQ ID NO:
- 6 that comprises SEQ ID NO:
- 8, and
- a carrier, which is at least one member selected from the group consisting of a bead, a test strip, a microtiter plate, a microarray, a solid polymer derived from cellulose, a line blot, a dot blot, a glass surface, a slide, and a biochip,
- wherein the polypeptide is immobilized on the diagnostically useful carrier.
3 more elements
A vaccine, comprising:
- a polypeptide comprising a sequence of SEQ ID NO:
- 6 that comprises SEQ ID NO:
- 8, an adjuvant, and at least one diluent, at least one glidant, and/or at least one filling agent.
A kit, comprising:
- a diagnostically useful carrier, and
- a labelled antigen that is recognized by an antibody to Ara h 7 isotype 7.0201, wherein the labelled antigen is selected from the group consisting of a sequence of SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, and SEQ ID NO:
- 10;
- wherein the diagnostically useful carrier comprises:
- a carrier having an immobilized antibody that recognizes and immobilizes IgE, IgG, or IgA class antibodies, wherein the IgE, IgG, or IgA class antibodies comprise the antibody to Ara h 7 isotype 7.0201, and
- said carrier selected from the group consisting of a bead, a test strip, a microtiter plate, a microarray, a solid polymer derived from cellulose, a line blot, a dot blot, a glass surface, a slide, a biochip, and a membrane.
7 more elements
Dependencies are inferred from the claim text.