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US 10,871,436 B2Granted
Particles containing detectable elemental code
AssigneeFluidigm Canada Inc.
InventorsMitchell A. Winnik, Cedric Van-Caeyzeele, Vladimir I. Baranov
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Abstract
The invention relates to a new type of element encoded particles suitable for the attachment of bio molecules to enable massively multiplex bio-analytical methods, and to calibrate and tune the elemental flow cytometer mass spectrometer (FC-MS).
Claims19
A first element encoded particle for use in elemental analysis with a mass analyzer, the first element encoded particle comprising:
- a unique combination of at least two staining elements, the at least two staining elements and the unique combination of the at least two staining elements selected such that, upon elemental analysis by the mass analyzer, a distinct signal is obtained from the combination of the at least two staining elements,
- wherein the distinct signal obtained from the combination of the two staining elements serve as a signature of the first element encoded particle that distinguishes the first element encoded particle from element encoded particles stained with a different staining element,
- wherein the at least two staining elements are each an isotope purified over other isotopes of a lanthanide element,
- wherein the first element encoded particle is distinguishable based on its isotopic composition,
- wherein an antibody is conjugated to the particle, and
- wherein the particle is polymeric.
3 more elements
Dependencies are inferred from the claim text.