Biomolecular processing platform and uses thereof

A device comprising:

• a biomolecular processor, each biomolecular processor comprising:
• one or more bioreactor chambers defined by a solid substrate;
• a support structure within each bioreactor chamber and attached to the solid substrate;
• a cleaving enzyme immobilized to the support structure and operatively positioned within said bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by said cleaving enzyme;
• and
• one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers, each of said one or more time-of-flight channels having an input end and an output end, wherein each of said one or more time-of-flight channels comprise two or more sensors including at least (i) a first sensor contacting each of the one or more time-of-flight channels proximate to the input end of the time-of-flight channel and forming a first nanogap within the time-of-flight channel, wherein said nanogap has a width that is less than the width of the time-of-flight channel, and (ii) a second sensor contacting each of the one or more time-of-flight channels proximate to the output end of the time-of-flight channel and forming a second nanogap within the time-of-flight channel, wherein said second nanogap has a width that is less than the width of the time-of-flight channel.