Compositions and methods for modulating neuronal excitability and motor behavior
AssigneesIcahn School of Medicine at Mount Sinai, The Rockefeller University
InventorsAnne Schaefer, Paul Greengard
Life of this patent
Estimating the term…
Abstract
The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method comprises administering to the central nervous system of an individual in need of such treatment a therapeutically effective amount of an agent capable of increasing the expression and/or activity of miR-128.
Claims9
A method for treating or reducing the likelihood of the development or occurrence of seizures in an individual at risk for or having seizures, wherein said individual has suffered a prior brain injury caused by hypoxia or a prior traumatic brain injury comprising administering to said individual a therapeutically effective amount of a miR-128 having the nucleotide sequence:
- (SEQ ID NO:
- 1)
- UCACAGUGAACCGGUCUCUUU.
Dependencies are inferred from the claim text.