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US 10,870,852 B2Granted
Compositions and methods for treating diabetic retinopathy
AssigneeUniversity of Virginia Patent Foundation
InventorsBijan K. Dey, Paul Andrew Yates
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AssigneeUniversity of Virginia Patent Foundation
InventorsBijan K. Dey, Paul Andrew Yates
Estimating the term…
The application discloses compositions and methods for preventing and treating diabetic retinopathy. It is disclosed herein that an inhibitor of microRNA-let-7b administered to the eye of a subject in need thereof is useful for preventing and treating several problems associated with diabetic retinopathy and plays a role in vasculature stabilization, increasing retinal thickness, reducing retinal capillary dropout, diminishing microvascular leakage, preventing or treating hyperproliferation of microvascular cells, and stabilizing aberrant neovascularization. The invention includes the use of various kinds of inhibitors of microRNA-let-7b, including, but not limited to, an antagomir of miRNA-let-7b. A useful compound of the invention can be administered into the eye, including intravitreally. A useful antagomir is Dy547-mA(*)mA(*)mCmCmAmCmAmCmAmAmCmCmUmAmCmUmAmCmCmU(*) mC(*)mA (*)(3′-Chl).
A method for treating a retinopathy, said method comprising providing a subject suffering from a retinopathy in which stabilization of vasculature in an eye of the subject is desired;
A method for inhibiting the effects of increased levels or activity of miRNA let-7b in a subject in need thereof, wherein said increased levels or activity are associated with a microvasculature injury, disease, or disorder of the eye, said method comprising providing a subject in which stabilization of vasculature in an eye of the subject is desired;
Dependencies are inferred from the claim text.