Non-coding RNAs linked to immortality and associated methods and compositions
AssigneesThe Regents of the University of California, Arizona Board of Regents on Behalf of the University of Arizona
InventorsMartha R. Stampfer, James C. Garbe, Lukas Vrba, Bernard W. Futscher
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Abstract
Aspects of the present disclosure include RNAs that confer a mortal phenotype and nucleic acids encoding same. Liposomes, recombinant cells, and pharmaceutical compositions that include the RNAs or nucleic acids encoding same are also provided. Further provided are methods involving quantifying MORT RNAs and/or determining the methylation status of the MORT promoter, as well as methods that employ the RNAs or nucleic acids encoding same.
Claims6
A complementary deoxyribonucleotide (cDNA) that encodes a ribonucleic acid (RNA) comprising the ribonucleotide sequence set forth in SEQ ID NO:7, or a variant RNA thereof comprising 99% or greater identity to, and across the entire length of, the ribonucleotide sequence set forth in SEQ ID NO:7 that confers a mortal phenotype, wherein the cDNA is operably linked to an RNA polymerase promoter.
Dependencies are inferred from the claim text.