Methods for inhibiting angiogenesis in a subject in need thereof
AssigneeUniversity of Leicester
InventorsGregory A. Demopulos, Hans-Wilhelm Schwaeble, Thomas Dudler, Larry Tjoelker
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Abstract
In one aspect, the present invention provides methods for preventing, treating, reverting and/or delaying angiogenesis in a mammalian subject suffering from, or at risk for developing, an angiogenesis-dependent disease or condition, comprising administering to the subject an amount of a MASP-2 inhibitory agent effective to inhibit angiogenesis. In some embodiments of these aspects of the invention, the MASP-2 inhibitory agent is a MASP-2 antibody or fragment thereof.
Claims3
A method for treating a mammalian subject suffering from an ocular angiogenesis-dependent disease selected from the group consisting of:
- proliferative diabetic retinopathy, vitreous hemorrhage secondary to proliferative diabetic retinopathy, neovascular glaucoma, corneal neovascularization, and retinopathy of prematurity, comprising administering to the subject an amount of a MASP-2 inhibitory agent effective to inhibit angiogenesis, wherein the MASP-2 inhibitory agent is a MASP-2 monoclonal antibody or antigen-binding fragment thereof comprising a heavy chain variable region comprising SEQ ID NO:67 and a light chain variable region comprising SEQ ID NO:69.
Dependencies are inferred from the claim text.