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US 10,870,705 B2Granted
Chimeric antigen receptors specific for carbonic acid anhydrase IX
AssigneeDana-Farber Cancer Institute, Inc.
InventorWayne A. Marasco
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Abstract
The present invention provides chimeric antigen receptor cells specific for carbonic anhydrase IX (CAIX) and methods of using same for treatment of CAIX expressing cancers such as renal cell carcinoma.
Claims8
A chimeric antigen receptor (CAR) comprising an intracellular signaling domain, a transmembrane domain and an extracellular domain, wherein the extracellular domain comprises comprising a carbonic-anhydrase-IX (G250)-specific antibody or fragment thereof, wherein the intracellular signaling domain comprises a CD3 zeta chain.
Dependencies are inferred from the claim text.