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US 10,870,704 B2Granted
CD83 binding proteins and uses thereof
AssigneeKira Biotech Pty Limited
InventorsJoanne L. Casey, Andrew M. Coley
Life of this patent
Estimating the term…
Abstract
An isolated or recombinant CD83 binding protein may include an antigen binding domain, wherein the antigen binding domain binds specifically to CD83 or a cell expressing CD83.
Claims17
A CD83 binding protein comprising an antigen binding domain which specifically binds to CD83, wherein the binding protein comprises:
- three heavy chain complementarity determining regions (VH CDRs) comprising amino acid sequences as shown in SEQ ID NO:3 (VH CDR1), SEQ ID NO:4 (VH CDR2), and SEQ ID NO:5 (VH CDR3);
- and
- (i) three light chain complementarity determining regions (VL CDRs) comprising amino acid sequences as shown in SEQ ID NO:51 (VL CDR1), SEQ ID NO:52 (VL CDR2), and SEQ ID NO:53 (VL CDR3);
- or
- (ii) three light chain complementarity determining regions (VL CDRs) comprising amino acid sequences as shown in SEQ ID NO:54 (VL CDR1), SEQ ID NO:55 (VL CDR2), and SEQ ID NO:56 (VL CDR3);
- or
- (iii) three light chain complementarity determining regions (VL CDRs) comprising amino acid sequences as shown in SEQ ID NO:57 (VL CDR1), SEQ ID NO:58 (VL CDR2), and SEQ ID NO:59 (VL CDR3);
- or
- (iv) three light chain complementarity determining regions (VL CDRs) comprising amino acid sequences as shown in SEQ ID NO:60 (VL CDR1), SEQ ID NO:61 (VL CDR2), and SEQ ID NO:62 (VL CDR3);
- or
- (v) three light chain complementarity determining regions (VL CDRs) comprising amino acid sequences as shown in SEQ ID NO:63 (VL CDR1), SEQ ID NO:64 CDR2), and SEQ ID NO:65 (VL CDR3);
- or
- (vi) three light chain complementarity determining regions (VL CDRs) comprising amino acid sequences as shown in SEQ ID NO:66 (VL CDR1), SEQ ID NO:67 CDR2), and SEQ ID NO:68 (VL CDR3);
- or
- (vii) three light chain complementarity determining regions (VL CDRs) comprising amino acid sequences as shown in SEQ ID NO:69 (VL CDR1), SEQ ID NO:70 CDR2), and SEQ ID NO:71 (VL CDR3);
- or
- (viii) three light chain complementarity determining regions (VL CDRs) comprising amino acid sequences as shown in SEQ ID NO:72 (VL CDR1), SEQ ID NO:73 CDR2), and SEQ ID NO:74 (VL CDR3);
- or
- (ix) three light chain complementarity determining regions (VL CDRs) comprising amino acid sequences as shown in SEQ ID NO:75 (VL CDR1), SEQ ID NO:76 CDR2), and SEQ ID NO:77 (VL CDR3);
- or
- (x) three light chain complementarity determining regions (VL CDRs) comprising amino acid sequences as shown in SEQ ID NO:78 (VL CDR1), SEQ ID NO:79 CDR2), and SEQ ID NO:80 (VL CDR3);
- or
- (xi) three light chain complementarity determining regions (VL CDRs) comprising amino acid sequences as shown in SEQ ID NO:81 (VL CDR1), SEQ ID NO:82 CDR2), and SEQ ID NO:83 (VL CDR3);
- or
- (xii) three light chain complementarity determining regions CDRs) comprising amino acid sequences as shown in SEQ ID NO:84 (VL CDR1), SEQ ID NO:85 CDR2), and SEQ ID NO:86 CDR3).
22 more elements
Dependencies are inferred from the claim text.