Back to results
US 10,870,701 B2Granted
Multispecific fab fusion proteins and use thereof
AssigneeGeneron (Shanghai) Corporation Ltd.
InventorsYumin Cui, Zhihua Huang, Hanyang Chen, Xinfeng Zhang, Bo Qi, Xiaoqiang Yan
Life of this patent
Estimating the term…
Abstract
The present invention provides multispecific Fab fusion proteins (MSFP) that specifically bind to CD3 and EpCAM. The present invention further provides uses of the MSFPs for the preparation of pharmaceutical compositions, methods of treating cancer, and kits comprising the MSFPs. Also provided are anti-EpCAM antibodies or antigen-binding fragments thereof.
Claims20
An anti-EpCAM antibody or antigen-binding fragment thereof, comprising a heavy chain variable region (VH) comprising:
- (1) a HVR-H1 comprising the amino acid sequence of SEQ ID NO:13;
- (2) a HVR-H2 comprising the amino acid sequence of SEQ ID NO:14;
- and (3) a HVR-H3 comprising the amino acid sequence of SEQ ID NO:15;
- and a light chain variable region (VL) comprising:
- (1) a HVR-L1 comprising the amino acid sequence of SEQ ID NO:16;
- (2) a HVR-L2 comprising the amino acid sequence of SEQ ID NO:17;
- and (3) a HVR-L3 comprising the amino acid sequence of SEQ ID NO:18.
4 more elements
Dependencies are inferred from the claim text.