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US 10,870,699 B2Granted
Anti-CD47 antibodies and uses thereof
AssigneeCelgene Corporation
InventorsAaron Sato, Ryan Stafford, Junhao Yang
Life of this patent
Estimating the term…
Abstract
Provided herein are compositions, methods and uses involving antibodies that specifically bind to human CD47. Also provided are uses and methods, such as therapeutic methods, diagnostic methods, and methods of making such antibodies.
Claims24
A monoclonal anti-CD47 antibody which specifically binds to human CD47, wherein the anti-CD47 antibody comprises a heavy chain variable region (VH) comprising the amino acid sequence:
- (SEQ ID NO:
- 20)
- X1QX2QLVQSGAEVKKX3GX4SVKVSCKASGFNIKDYYLHWVRQAPGQX5
- LEWMGWIDPDQGDTEYAQKX6QX7RVTX8TX9DX10SX11STAYMELX12
- SLRSX13DTAX14YYCNAAYGSSSYPMDYWGQGTTVTV,
- wherein X1 is M or there is no amino acid at position X1, X2 is M or V, X3 is P, X4 is S or A, X5 is A or G, X6 is F or L, X7 is G, X8 is I or M, X9 is R or T, X10 is R or T, X11 is T, X12 is R, X13 is E or D, and X14 is V;
- and
- wherein the anti-CD47 antibody comprises a light chain variable region (VL) comprising CDR1, CDR2, and CDR3 comprising amino acid sequences KASQDIHRYLS (SEQ ID NO:17), RANRLVS (SEQ ID NO:
- 18), and LQYDEFPYT (SEQ ID NO:19), respectively.
6 more elements
Dependencies are inferred from the claim text.