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AssigneeThe United States of America as represented by the Secretary, Department of Health and Human Service
InventorsChristian S. Hinrichs, Steven A. Rosenberg
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Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E7, E711-19. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.
A T cell receptor (TCR) comprising a human variable region and a murine constant region, or a functional variant of the TCR, wherein the TCR and the functional variant comprise the amino acid sequences of SEQ ID NOs:
An isolated or purified polypeptide comprising the amino acid sequences of (a) SEQ ID NOs:
An isolated or purified protein comprising a first polypeptide chain comprising the amino acid sequences of SEQ ID NOs:
A protein comprising SEQ ID NO:
Dependencies are inferred from the claim text.