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AssigneeDalian Medical University
InventorsJie Zhao, Shao Li, Wanqin Zhang
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A scorpion venom heat-resistant synthetic peptide (SVHRSP) contains an amino acid sequence of SEQ ID NO 1. One or more amino acids the amino acid sequence can be substituted or deleted. A pharmaceutical composition that contains the SVHRSP has numerous applications. The pharmaceutical composition can be used to protect neuronal cell against amyloid beta-induced toxic effects, or to inhibit the sodium channel current of a hippocampal neuronal cell, or to protect a neuronal cell against NMDA-induced injury. It may also promote the formation of a pluripotent neural stem cell from a type II astrocyte, or treats a subject, such as a human, having epilepsy, Alzheimer's disease, or Parkinson's disease.
A method of alleviating symptoms of a neurological disease associated with amyloid beta-induced toxic effect, oxidative stress, or NMDA-induced injury, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition, wherein the pharmaceutical composition comprises a scorpion venom heat-resistant synthetic peptide (SVHRSP) consisting of the amino acid sequence of SEQ ID NO 1 and the neurological disease is epilepsy, Alzheimer's disease, or Parkinson's disease.
A method of protecting a neuronal cell against an adverse effect, the method comprising contacting the neuronal cell with an effective amount of a pharmaceutical composition in vitro, wherein the pharmaceutical composition comprises a scorpion venom heat-resistant synthetic peptide (SVHRSP) consisting of the amino acid sequence of SEQ ID NO 1 and the adverse effect is amyloid beta-induced toxic effect, oxidative stress, or NMDA-induced injury.
A method of inhibiting the sodium channel current of a hippocampal neuronal cell, the method comprising contacting the hippocampal neuronal cell with an effective amount of a pharmaceutical composition in vitro, wherein the pharmaceutical composition comprises a scorpion venom heat-resistant synthetic peptide (SVHRSP) consisting of the amino acid sequence of SEQ ID NO 1.
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