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US 10,870,662 B2Granted
Alpha-amino pateamine A derivatives and methods for treating chronic lymphocytic leukemia
AssigneeThe Texas A&M University System
InventorsDaniel Romo, Ken Hull, Mingzhao Zhu, Omar Robles
Life of this patent
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Abstract
Pateamine A derivatives and pharmaceutical compositions that include the derivatives. The pateamine A derivatives are α-amino pateamine A derivatives that lack the C5-methyl group of pateamine A.
Claims21
A compound having the formula:
- or a stereoisomer, racemate, or a pharmaceutically acceptable salt thereof,
- wherein
- Z is selected from R and OR′,
- wherein R is selected from C1-C6 alkyl, C1-C6 haloalkyl, C6-C10 aryl, and C3-C12 alkyl groups in which one or more carbons are replaced with O, NH, or N(CH3), and
- wherein R1 is selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C6-C10 aryl, and C3-C12 alkyl groups in which one or more carbons are replaced with O, NH, or N(CH3).
2 more elements
Dependencies are inferred from the claim text.