Nitrogen-containing tricyclic derivatives having HIV replication inhibitory activity

A compound of formula (I-1-1B)

• or a pharmaceutically acceptable salt thereof,
• wherein R1 is alkyl or halogen;
• R2 is alkyloxy;
• R3 is aromatic carbocyclyl optionally substituted with halogen, alkyl and/or alkyloxy, non-aromatic carbocyclyl optionally substituted with halogen, alkyl and/or alkyloxy, aromatic heterocyclyl optionally substituted with halogen, alkyl and/or alkyloxy, or non-aromatic heterocyclyl optionally substituted with halogen, alkyl and/or alkyloxy, the aromatic carbocyclyl is phenyl, the non-aromatic carbocyclyl is a cyclic saturated hydrocarbon group or a cyclic unsaturated non-aromatic hydrocarbon, which is C3 to C16 monocyclic or C8 to C13 polycyclic having two or more rings, wherein non-aromatic carbocyclyl which is polycyclic having two or more rings may be a fused cyclic group where a non-aromatic carbocyclyl, which is monocyclic or polycyclic having two or more rings, is fused with a ring of the aromatic carbocyclyl, the non-aromatic carbocyclyl may be a group having a bridge or a group to form a spiro ring, the aromatic heterocyclyl is 5 or 6-memebered monocyclic or 9 or 10-membered polycyclic having two rings, containing one or more and same or different heteroatoms selected from O, S and N, the non-aromatic heterocyclyl is 5 or 6-membered monocyclic or 8 to 20 membered polycyclic having two or more rings, containing one or more and same or different heteroatoms arbitrarily selected from O, S and N, wherein non-aromatic heterocyclyl which is polycyclic having two or more rings may be a fused cyclic group where a non-aromatic heterocyclyl which is monocyclic or polycyclic having two or more rings, is fused with a ring of the aromatic carbocyclyl non-aromatic carbocyclyl, and/or aromatic heterocyclyl, and the non-aromatic heterocyclyl may be a group having a bridge by alkylene, or a group to form a spiro ring with alkylene;
• R4 is hydrogen;
• R3A is hydrogen or halogen;
• R4A is alkyl optionally substituted with cyano, halogen, hydroxy or alkyloxy, halogen, alkynyl, or 3-membered non-aromatic carbocyclyl;
• Ra is each independently aromatic heterocyclyl optionally substituted with one or more groups selected from Substituent Group E or non-aromatic heterocyclyl optionally substituted with one or more groups selected from Substituent Group E, the aromatic heterocyclyl is 5 or 6-memebered monocyclic or 9 or 10-membered polycyclic having two rings, containing one or more and same or different heteroatoms selected from O, S and N, the non-aromatic heterocyclyl is 5 or 6-membered monocyclic or 8 to 16 membered polycyclic having two or more rings, containing one or more and same or different heteroatoms arbitrarily selected from O, S and N, and the Substituent Group E is alkyl, halogen, alkyloxy, dialkylamino alkyloxy, alkylamino alkyloxy, amino alkyloxy, non-aromatic heterocyclylalkyl oxy, non-aromatic heterocyclyloxy optionally substituted with alkyl and/or oxo, non-aromatic heterocyclyl optionally substituted with alkyl and/or oxo, dialkylamino alkyl, alkylamino alkyl, amino alkyl, non-aromatic heterocyclylalkyl, and aromatic heterocyclyl optionally substituted with alkyl, wherein the aromatic heterocyclyl is 5 or 6-memebered monocyclic or 9 or 10-membered polycyclic having two rings, containing one or more and same or different heteroatoms selected from O, S and N, and the non-aromatic heterocyclyl is 3 to 8-membered monocyclic containing one or more and same or different heteroatoms arbitrarily selected from O, S and N;
• Rb is each independently hydrogen, alkyl, haloalkyl, or alkyloxyalkyl;
• and
• Rc is each independently hydrogen, alkyl, haloalkyl, or alkyloxyalkyl.