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US 10,870,650 B2Granted
Process for the preparation of amorphous idelalisib
AssigneeNatco Pharma Limited
InventorsAmala Kompella, Sreenivas Rachakonda, Venugopala Krishna Gampa, Subhash Kusumba, Durga Prasad Konakanchi, Pulla Reddy Muddasani, Venkaiah Chowdary Nannapaneni
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Abstract
The present invention relates to a process for the preparation of stable and 5 pure amorphous form of Idelalisib. Further, the present process is simple, more economical, cost effective and efficient method of manufacturing that is suitable for industrial scale-up having a high degree of chromatographic purity.
Claims17
A process for the preparation of the compound of Formula G:
- the process comprising reacting the compound of Formula C:
- with an acid chloride in a halogenated hydrocarbon solvent to obtain the compound of Formula D:
- which is treated with 2-amino-6-fluoro-benzoic acid in a polar aprotic solvent to obtain the compound of Formula E:
- which is further treated with diphenylphosphine and pyridine in a polar aprotic solvent to obtain the compound of Formula F:
- followed by treatment with aniline to obtain the compound of Formula G.
2 more elements
Dependencies are inferred from the claim text.