Histone demethylase inhibitors

A method inhibiting a histone demethylase enzyme selected from a group comprising FBXL10, JARID1B, JMJD2C and JMJD3 comprising contacting a histone demethylase enzyme with an effective amount of a compound of Formula I

• wherein a compound of Formula I is optionally a pharmaceutically acceptable salt thereof, and wherein:
• R1 is halogen, CH2G, NHG, or OG, wherein
• G is hydrogen, alkyl, or XY, in which
• X is a bond, hydrogen, or C1 alkyl, and
• Y is carbocyclyl optionally substituted with aralkyl, carbocyclylalkyl, aryl optionally substituted with halogen, alkyl or carbocyclyl, —Rb—ORa, —Rb—OC(O)—Ra, —Rb—OC(O)—ORa, —Rb—OC(O)—N(Ra)2, —Rb—N(Ra)2, —Rb—C(O)Ra, —Rb—C(O)ORa, —Rb—O—Rc—C(O)N(Ra)2, —Rb—N(Ra)C(O)ORa, —Rb—N(Ra)C(O)Ra, —Rb—N(Ra)S(O)tRa, —Rb—S(O)tORa, —Rb—S(O)tORa, or —Rb—S(O)tN(Ra)2, wherein
• each Ra is independently hydrogen, alkyl, fluoroalkyl, cycloalkyl, cycloalkylalkyl, aryl, or aralkyl,
• each Rb is independently a direct bond or a straight or branched alkylene, alkenylene chain, carbocyclyl, or aryl optionally substituted by halogen,
• each Rc is a straight or branched alkylene or alkenylene chain;
• and
• t is 1 or 2;
• and
• R2 is halogen or CF3;
• and
• R5 is hydrogen, methyl, ethyl, isoproplyl, t-butyl, CHF2, CH2F, CF3, CH2OH, CHCH3OH, or C(CH3)2OH.