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US 10,870,621 B2Granted
Method for preparing latanoprostene bunod, and intermediate therefor
AssigneeYonsung Fine Chemical Co., Ltd.
InventorsEun Jeong Ko, Hyun Ik Shin, Kee Young Lee, Chang Young Oh
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for preparing latanoprostene bunod and an intermediate therefor. In accordance with the preparation process of the present invention, latanoprostene bunod can be efficiently and cost-effectively prepared while reducing side reactions.
Claims8
A process for preparing latanoprostene bunod of the following formula (1), which comprises the steps of:
- (i) subjecting a compound of the following formula (3) to esterification with a compound of the following formula (4) to obtain a compound of the following formula (5);
- and
- (ii) subjecting the bromide of the compound of the following formula (5) to nitration:
A compound of the following formula (5):
A process for preparing a compound of the following formula (5), which comprises a step of:
- (i) subjecting a compound of the following formula (3) to esterification with a compound of the following formula (4):
Dependencies are inferred from the claim text.