Apparatus for applying electric pulses to living myocardial tissue

An apparatus for applying at least one electric pulse to a living myocardial tissue, the apparatus comprising:

• an input configured to receive an electric signal representing a present electric activity of the myocardial tissue;
• a computing device that comprises a processor and memory;
• a plurality of machine instructions stored in memory, wherein when executed, the machine instructions causes the processor to at least:
• determine that a dominant frequency of the electric signal is above a predetermined frequency threshold;
• in response to the dominant frequency being above the predetermined frequency threshold, calculate a present permutation entropy value of the electric signal in the state space, wherein a control signal is generated for a pulse generator when the calculated present permutation entropy value of the electric signal is lower than a predetermined entropy threshold value,
• wherein the present permutation entropy value of the electric signal is calculated as a present permutation entropy Sp according to
• Sp=−ΣPm×log(Pm) for M=1, . . . ,D!
• for a series of N values of the electric signal sampled at intervals ΔT,
• wherein Pm is a number of occurrences of a respective one of D! different motifs of D consecutive values separated by L values in the series of the N values divided by the total number of occurrences of all different motifs which is (N (D-1) x L),
• wherein L x ΔT is in a range from 0.1 ms to 250 ms and N x ΔT is in a range from 100 ms to 10 s, and
• wherein D is in a range from 2 to 6;
• cause the pulse generator to generate the at least one electric pulse in response to the control signal being generated;
• and
• cause a generation of an output to the at least one electric pulse to the myocardial tissue.