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US 10,870,005 B2Granted
Neurostimulation titration utilizing T-wave alternans
AssigneeLivaNova USA, Inc.
InventorsImad Libbus, Bruce H. KenKnight
Life of this patent
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Abstract
Systems and methods are provided for delivering neurostimulation therapies to patients. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level until a target T-wave alternans change from a baseline T-wave alternans is achieved.
Claims18
A method of operating an implantable medical device (IMD) comprising a neurostimulator coupled to an electrode assembly, said neurostimulator adapted to deliver a stimulation signal to a patient, said method comprising:
- computationally determining a current cardiac magnitude value for the patient, wherein the cardiac magnitude value comprises a T-wave alternans (TWA) magnitude value;
- activating the IMD to deliver to the patient a plurality of stimulation signals at increasing stimulation intensities until the current cardiac magnitude value reaches a target cardiac magnitude;
- and
- activating the IMD to deliver a therapeutic level of stimulation corresponding to the stimulation intensity in response to which the current cardiac magnitude value reached the target cardiac magnitude.
1 more element
A neurostimulation system, comprising:
- an implantable medical device (IMD) comprising:
- an electrode assembly;
- a neurostimulator coupled to the electrode assembly, wherein the neurostimulator is adapted to deliver a stimulation signal to a patient;
- and
- a control system programmed to:
- computationally determine a current cardiac magnitude value for the patient, wherein the cardiac magnitude value comprises a T-wave alternans (TWA) magnitude value;
- activate the IMD to deliver to the patient a plurality of stimulation signals at increasing stimulation intensities until the current cardiac magnitude value reaches a target cardiac magnitude;
- and
- activate the IMD to deliver a therapeutic level of stimulation corresponding to the stimulation intensity in response to which the current cardiac magnitude value reached the target cardiac magnitude.
6 more elements
A neurostimulation system, comprising:
- an implantable medical device (IMD) comprising:
- an electrode assembly;
- a neurostimulator coupled to the electrode assembly, wherein the neurostimulator is adapted to deliver a stimulation signal to a patient;
- an electrodcardiogram (ECG) sensor;
- and
- a control system programmed to:
- activate the IMD to deliver to the patient a plurality of stimulation signals;
- monitor the ECG of the patient using the ECG sensor;
- and
- determine a cardiac value based on the monitored ECG, wherein the cardiac value comprises a T-wave alternans (TWA) value.
7 more elements
Dependencies are inferred from the claim text.