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US 10,869,941 B2Granted
Gas-generating polymer micells and manufacturing method of the same
AssigneesIndustry-University Cooperation, Foundation Hanyang University
InventorsKuen Yong Lee, Eun Ju Jeong
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Abstract
The present invention relates to a gas-generating micelle prepared by coupling a polyethylene glycol derivative and an alkyl chloroformate. The gas-generating micelles according to the present invention are circulated in the body and deposited on the disease site to generate carbon dioxide, and thus a more enhanced ultrasonic diagnostic image can be obtained.
Claims3
A method of preparing a gas-generating micelle including a compound represented by the following Formula 1, the method comprising:
- mixing polyethylene glycol and an alkyl chloroformate to synthesize a polyethylene glycol derivative;
- wherein the polyethylene glycol derivative is represented by Formula I, and
- dissolving the polyethylene glycol derivative in one solvent selected from acetonitrile, methylene chloride, chloroform, and methanol or in a solvent mixture of two or more selected therefrom and then evaporating the solvent(s), and then dispersing the polyethylene glycol derivative in an aqueous solution,
- wherein R1 is a C1 to C2 alkyl group, H, —NH2, or COOH,
- p is an integer ranging from 12 to 227,
- q is an integer ranging from 2 to 14, and
- wherein the micelle has a diameter of 150 to 500 nm.
4 more elements
Dependencies are inferred from the claim text.