Targeted photoacoustic compounds, formulations, and uses thereof
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsSanjiv S. Gambhir, Jelena Levi
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Abstract
Provided herein are targeted photoacoustic compounds and formulations thereof that can contain a photoacoustic signaling moiety operatively coupled to a targeting moiety. Also provided herein are methods of imagining a subject using the targeted photoacoustic compounds and formulations thereof provided herein.
Claims9
A method of imaging a target cell in a subject in need thereof, comprising:
- administering a photoacoustic compound to the subject in need thereof;
- applying a light to the area of the subject to be imaged;
- and
- detecting ultrasonic waves emitted from the photoacoustic compound,
- wherein the photoacoustic compound consists of a targeting moiety and a photoacoustic signaling molecule, wherein the photoacoustic signaling molecule is coupled to the targeting moiety via a linker, and wherein the photoacoustic signaling molecule is selected from the group consisting of:
- Evans blue, lymphazurin, methylene blue, ATTO-610, ATTO-620, ATTO-Rho 14, ATTO-633, ATTO-647, ATTO-647N, ATTO-655, ATTO-Oxa12, ATTO-665, ATTO-680, ATTO-700, ATTO, 725, and ATTO-740, and wherein the targeting moiety has a Formula according to any one of Formulas 2-9, and 12:
- wherein, in Formula 6, R is H or —O-Me, and in Formula 7, n is between 1 and 50.
A compound consisting of a targeting moiety and a photoacoustic signaling molecule, wherein the photoacoustic signaling molecule is coupled to the targeting moiety via a linker, and wherein the photoacoustic signaling molecule is selected from the group consisting of:
- Evans blue, lymphazurin, methylene blue, ATTO-610, ATTO-620, ATTO-Rho 14, ATTO-633, ATTO-647, ATTO-647N, ATTO-655, ATTO-Oxa12, ATTO-665, ATTO-680, ATTO-700, ATTO, 725, and ATTO-740, and wherein the targeting moiety has a Formula according to any one of Formulas 2-9, and 12:
- wherein, in Formula 6, R is H or —O-Me, and in Formula 7, n is between 1 and 50.
A pharmaceutical formulation comprising a photoacoustic compound consisting of a targeting moiety and a photoacoustic signaling molecule, wherein the photoacoustic signaling molecule is coupled to the targeting moiety via a linker, and wherein the photoacoustic signaling molecule is selected from the group consisting of:
- Evans blue, lymphazurin, methylene blue, ATTO-610, ATTO-620, ATTO-Rho 14, ATTO-633, ATTO-647, ATTO-647N, ATTO-655, ATTO-Oxa12, ATTO-665, ATTO-680, ATTO-700, ATTO, 725, and ATTO-740, and wherein the targeting moiety has a Formula according to any one of Formulas 2-9, and 12:
- wherein, in Formula 6, R is H or —O-Me, in Formula 7, n is between 1 and 50;
- and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.