RNA containing composition for treatment of tumor diseases
AssigneeCureVac AG
InventorsMariola Fotin-Mleczek, Aleksandra Kowalczyk, Regina Heidenreich, Patrick Baumhof, Jochen Probst, Karl-Josef Kallen
Life of this patent
Estimating the term…
Abstract
The present invention relates to RNA containing compositions for use in the treatment or prophylaxis of tumor and/or cancer diseases, to a pharmaceutical composition, to a kit and to uses of the RNA containing compositions for the treatment or prophylaxis of tumor and/or cancer diseases.
Claims23
A method of treating cancer in a patient having a solid tumor, the method comprising administering to the patient, by intratumoral application, a pharmaceutically effective amount of a composition comprising an mRNA encoding IL-12, wherein the mRNA encodes the sequence of wild type human IL-12 or a sequence at least 90% identical to mature IL-12 and having IL-12 activity and wherein the mRNA is complexed with one or more lipids, thereby forming liposomes, lipid nanoparticles and/or lipoplexes.
Dependencies are inferred from the claim text.