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US 10,869,933 B2Granted
Oligomer-phenothiazine conjugates
AssigneeNektar Therapeutics
InventorsXuyuan Gu, Jennifer Riggs-Sauthier
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Abstract
The invention relates to (among other things) oligomer-phenothiazine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated phenothiazine compounds.
Claims18
A method of treating allergic reactions, anaphylaxis, motion sickness, nausea, or visceral pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound having the formula:
- R1, R2, R3, and R4, each independently are selected from the group consisting of hydrogen, unsubstituted alkyl, and substituted alkyl;
- or R3 and R4 together with the nitrogen form a heterocycle;
- n is an integer equal to or greater than one;
- X is a spacer moiety;
- and
- POLY is a poly(ethylene oxide) polymer.
3 more elements
Dependencies are inferred from the claim text.