Back to results
US 10,869,932 B2Granted
Compositions and methods for modifying the surface of cells and methods of use
AssigneeUniversity of Utah Research Foundation
InventorsYoung-Wook Won, David A. Bull, Amit N. Patel
Life of this patent
Estimating the term…
Abstract
Described herein are compounds, compositions and methods for modification of the surface of a living cell with a therapeutically relevant targeting moiety. Also described herein are methods for treating disease states, such as acute myocardial ischemia or infarction, with said compositions, in a subject.
Claims14
A method of localizing a cell to a location having associated therewith a target ligand, the method comprising delivering to the location a composition comprising a cell bound to the compound of formula (I):
- L-Y—X-T (I)
- wherein
- L is a phospholipid selected from the group consisting of 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine and 1,2-distearoyl-sn-glycero-3-phosphocholine;
- Y is a poly(ethylene glycol) having a molecular weight between about 2 kDa and about 10 kDa;
- X is a linker derived from a reactive functional group;
- and
- T is a targeting moiety adapted to bind to the target ligand.
4 more elements
Dependencies are inferred from the claim text.