US 10,869,927 B2 · Human endothelin receptor antibody and use thereof

Abstract

The present invention discloses an antibody specifically binding to a human endothelin receptor and uses thereof, where the antibody can inhibit the functions of the human endothelin receptor. The present invention includes the preparation, cloning, expression, and characterization of the antibody. The present invention can be used to effectively treat pulmonary arterial hypertension, a disease associated with pulmonary arterial hypertension, and a reproductive organ cancer in a human.

Claims9

Dependent claims

An antibody that specifically binds to a human endothelin receptor comprising:

light chain CDR1 amino acid sequence:
SEQ ID NO:
24;
light chain CDR2 amino acid sequence:
SEQ ID NO:
44;
light chain CDR3 amino acid sequence:
SEQ ID NO:
62;
heavy chain CDR1 amino acid sequence:
SEQ ID NO:
84;
heavy chain CDR2 amino acid sequence:
SEQ ID NO:
108;
and
heavy chain CDR3 amino acid sequence:
SEQ ID NO:
130.

16 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/538,509Filed 12 Aug 2019 · continuation

Priority

CN 2015 1 08672881 Dec 2015

Published

US 2019/0365894 A15 Dec 2019

Granted

22 Dec 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 39/39558
Against materials from animals: against tumor tissues, cells, antigens
A61P 9/12
Drugs for disorders of the cardiovascular system: antihypertensives
C07K 16/26
Against material from animals or humans: against hormones ; against hormone releasing or inhibiting factors
C07K 16/28
Against material from animals or humans: against receptors, cell surface antigens or cell surface determinants

Family

PCT/CN2016/090960Parent of this continuation · filed 22 Jul 2016

US 2019/0365894 A1Pre-grant publication · published 5 Dec 2019

Application15/537,190Parent of this continuation

US 10,376,581 B2Parent of this continuation

US 2018/0256714 A1Published application

US 10,869,927 B2This patent

From the US filing history. Foreign family members aren’t listed.

Human endothelin receptor antibody and use thereof

Life of this patent

Human endothelin receptor antibody and use thereof

Life of this patent

Abstract

Claims9