PD-L1 antagonist combination treatments
AssigneesMerck Patent GmbH, Pfizer Inc.
InventorsGlen Ian Andrews, Shihao Chen, Alessandra Di Pietro, David Fontana, Zelanna Goldberg, Chia-Yang Lin, Hua Long, Marcella Martignoni, Dimitry Serge Antoine Nuyten, Aron David Thall, Adrian Woolfson
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Abstract
The present disclosure describes combination therapies comprising an antagonist of Programmed Death Ligand 1 receptor (PD-L1) and another therapeutic agent, and the use of the combination therapies for the treatment of cancer.
Claims24
A method for treating a cancer in a human subject comprising administering to the subject a combination therapy which comprises an antagonist of a Programmed Death Ligand 1 protein (PD-L1) and a VEGFR inhibitor, wherein the PD-L1 antagonist is an anti-PD-L1 monoclonal antibody comprising:
- three CDRs from a heavy chain variable region comprising the amino acid sequence shown in SEQ ID NO:
- 8, and three CDRs from a light chain variable region comprising the amino acid sequence shown in SEQ ID NO:
- 9, wherein the VEGFR inhibitor is N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide or a pharmaceutically acceptable salt thereof and wherein the cancer is renal cell carcinoma.
A method for treating renal cell carcinoma in a human subject comprising administering to the subject a combination therapy which comprises avelumab and axitinib, wherein avelumab is administered about once every two weeks, and axitinib is administered twice daily.
A method for treating renal cell carcinoma in a human subject comprising administering to the subject a combination therapy which comprises avelumab and axitinib, wherein avelumab is administered about once every two weeks as a 1-hour intravenous infusion.
Dependencies are inferred from the claim text.