Alhydrogel-sodium chloride compound immunologic adjuvant, preparation method and use thereof

A method for preparing a vaccine, said method comprising combining sodium chloride and water fro injection and allowing a mass fraction of sodium chloride to reach 2.7%-4.5% before the vaccine is used, wherein said method comprises the following steps:

• adding the water for injection and the sodium chloride to an antigen, then adding an alhydrogel adjuvant, and allowing the mass fraction of sodium chloride in the prepared vaccine to reach 2.7%-4.5% before the vaccine is used;
• or directly dissolving the antigen in water, adding a hypertonic alhydrogel stock solution, and allowing the mass fraction of sodium chloride in the prepared vaccine to reach 2.7%-4.5%;
• or directly adding an adjuvant of sodium chloride in the preparation process, and allowing the mass fraction of sodium chloride in the prepared vaccine to reach 2.7%-4.5% before injection, if the vaccine to be prepared already contains the antigen and the alhydrogel.

A method for preparing a vaccine, said method comprising combining sodium chloride and water for injection, wherein a final mass fraction of the sodium chloride in the prepared vaccine is 3.6%.