Acinetobacter o-oligosaccharyltransferases and uses thereof
AssigneeVaxnewmo LLC
InventorsMario Feldman, Mohamed Adel Nasr
Life of this patent
Estimating the term…
Abstract
The present application provides methods and uses of O-oligosaccharyltransferase (O-OTases) for generating vaccines. In particular, the present application provides a method of synthesizing a glycoprotein comprising glycosylation of pilin-like protein ComP using a PglLComP O-OTase. Uses of glycoproteins synthesized by glycosylating ComP using PglLComP O-OTase, particularly for the preparation of vaccines and the like, including a vaccine to Streptococcus, is also provided.
Claims16
A method of glycosylating a protein in a bacterial cell, the method comprising glycosylating a fusion protein comprising ComP, with an N-glycan in a bacterial cell, using a PglLComP O-oligosaccharyltransferase.
Dependencies are inferred from the claim text.